Category · ranked by fit
GLP-1 Support & "Natural GLP-1" Supplements
GLP-1 is the gut hormone behind the prescription weight drugs everyone is talking about. A wave of supplements now claims to support your body’s own GLP-1 — through butyrate, prebiotic fibers, bitter compounds, or probiotics. None of them are GLP-1 drugs, and the evidence varies widely. Here is how the main "natural GLP-1" options compare on what they actually contain, at what dose, and how convincing the science is.
Ranked by how well each product fits this category on our five-axis rubric — with the specific mechanism each one uses to belong here.
- #1
Ozzi V2 Crave Crusher Ozzi · drink21/25 Exceptional valueBest DrinkBest for After-Dinner CravingsHow it fits: Ozzi pairs a near-zero-glucose-impact allulose base with six actives that between them cover every dimension of hunger we track: blood-sugar stability and the steady energy that comes with it (allulose), insulin sensitivity (Metabolex chromium), GLP-1 / gut-hormone signaling and the microbiome metabolite behind it (BIOMEnd butyrate), viscous-fiber fullness (glucomannan), and leptin/fat signaling (African mango) — all seven hunger pathways in one caffeine-free drink.
allSWEET 8 g Glucomannan 0.5 g BIOMEnd 0.5 g - #2
Ozzi Crave Crusher Capsules Ozzi · pill20/25 Great valueBest CapsuleHow it fits: The capsule is Ozzi’s drink formula minus the allulose sweet base that only fits a stick pack. It keeps the core actives: BIOMEnd butyrate for the GLP-1 / gut-hormone axis, glucomannan for viscous-fiber fullness, African mango for leptin and fat signaling, and Metabolex chromium for insulin sensitivity, covering five of the seven hunger pathways in a swallow-and-go pill.
Glucomannan 0.5 g BIOMEnd 0.5 g - #3
Lemme GLP-1 Daily (Lemme Reset) Lemme · pill18/25 Fair valueBest Celebrity BrandHow it fits: Three standardized plant extracts the brand says work together to support the body’s own GLP-1 production, reduce hunger and cravings, and support healthy weight management. Lemme states it is not GLP-1, not synthetic GLP-1, and not a GLP-1 drug.
Eriomin 200 mg - #4
NOW Berberine Glucose Support NOW Foods · pill17/25 Fair valueHow it fits: Berberine positioned to support healthy glucose metabolism already in the normal range, delivered in a softgel with MCT oil intended to improve absorption.
Berberine HCl 400 mg MCT Oil 700 mg - #5
Thorne Berberine (1,000 mg) Thorne · pill17/25 Good valueHow it fits: Berberine is a plant alkaloid the brand says supports healthy glucose and lipid metabolism, partly via the AMPK energy-sensing pathway, with the phytosome form intended to improve absorption.
Berberine HCl 450 mg Berberine Phytosome 550 mg - #6
Calocurb GLP-1 Activator Calocurb · pill16/25 Limited valueHow it fits: Calocurb is built around Amarasate, a patented bitter hops-flower extract. Its bitter compounds activate bitter taste receptors (TAS2Rs) in the gut, triggering release of the appetite-regulating hormones GLP-1, CCK, and PYY — the same gut-hormone axis the GLP-1 conversation centers on — to blunt hunger before a meal.
Amarasate 250 mg - #7
Supergut GLP-1 Daily Support Supergut · drink16/25 Great valueHow it fits: A blend of soluble, insoluble, and resistant prebiotic fibers (6–7 g total per serving) marketed to nourish beneficial gut bacteria and support the body’s natural GLP-1 activity, promoting satiety and curbing cravings.
Solnul proprietary Oat beta-glucan proprietary Green banana resistant starch proprietary Soluble vegetable fiber proprietary - #8
Pendulum GLP-1 Probiotic Pendulum Therapeutics · pill15/25 Fair valueHow it fits: Probiotic strains described as producing short-chain-fatty-acid postbiotics (butyrate, propionate, acetate) and the metabolite p9 in the gut, which the brand says supports the body’s own GLP-1 signaling and satiety.
Akkermansia muciniphila proprietary Clostridium butyricum proprietary Bifidobacterium infantis proprietary Probiotic blend 500 million AFU - #9
Evolv GLP-1 Evolv · pill12/25 Limited valueHow it fits: Marketed as an oral "biomimetic" peptide: the brand says it engineered a novel peptide (EV1), grew it inside Saccharomyces cerevisiae, and dried the yeast into a powder, and that the peptide then survives digestion and interacts with GLP-1 and GIP receptors in the gut and brain to support fullness and appetite regulation.
EV1 Peptide 560 mg